[6-羟基-2-(4-羟基苯基)苯并[B]噻酚-3-基][4-[2-(1-哌啶基)乙氧基]苯基]甲酮
Raloxifene
CAS: 84449-90-1
Molecular Formula: C28H27NO4S
[6-羟基-2-(4-羟基苯基)苯并[B]噻酚-3-基][4-[2-(1-哌啶基)乙氧基]苯基]甲酮 - Names and Identifiers
| Name | Raloxifene |
| Synonyms | Evista RALOXAFINE Raloxifene [4-[2-(1-Piperidinyl) Ethoxy] Phenyl]methanone.HCL [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-y1][4-[2-(1-piperidinyl)ethoxy]phenyl]methamone [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl] ketone Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]- [6-hydroxy-2-(4-hydroxyphenyl)benzothiophen-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]methanone hydrochloride |
| CAS | 84449-90-1 |
| EINECS | 686-786-1 |
| InChI | InChI=1/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,30-31H,1-3,14-17H2 |
[6-羟基-2-(4-羟基苯基)苯并[B]噻酚-3-基][4-[2-(1-哌啶基)乙氧基]苯基]甲酮 - Physico-chemical Properties
| Molecular Formula | C28H27NO4S |
| Molar Mass | 473.58 |
| Density | 1.289±0.06 g/cm3(Predicted) |
| Melting Point | 250-253°C |
| Boling Point | 728.2±60.0 °C(Predicted) |
| Water Solubility | 560μg/L at 25℃ |
| Solubility | DMSO: 28mg/mL, soluble |
| Appearance | solid |
| Color | light yellow |
| pKa | 8.83±0.15(Predicted) |
| Storage Condition | Desiccate at +4°C |
| Physical and Chemical Properties | Crystallization from acetone, melting point 143-147 °c. UV absorption maximum (ethanol):290nm (λ34000). Raloxifene Hydrochloride: C28H27NO4S? HCl. [8264000408]. Crystallization from methanol-water, melting point 258 °c. UV absorption maximum (ethanol):286NM (λ328 00). |
[6-羟基-2-(4-羟基苯基)苯并[B]噻酚-3-基][4-[2-(1-哌啶基)乙氧基]苯基]甲酮 - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29349990 |
[6-羟基-2-(4-羟基苯基)苯并[B]噻酚-3-基][4-[2-(1-哌啶基)乙氧基]苯基]甲酮 - Nature
Open Data Verified Data
crystallized from acetone, melting point 143-147 °c. UV absorption maximum (ethanol);290nm(e34000).
Last Update：2024-01-02 23:10:35
[6-羟基-2-(4-羟基苯基)苯并[B]噻酚-3-基][4-[2-(1-哌啶基)乙氧基]苯基]甲酮 - Preparation Method
Open Data Verified Data
2 (4-hydroxyphenyl) benzo [B] thiophene-6 monoalcohol is esterified with methanesulfonyl chloride to produce Diester with 4-(2-piperidinyl ethoxy) benzoyl chloride is subjected to acylation reaction, and raloxifene is obtained by hydrolysis.
Last Update：2022-01-01 09:24:21
[6-羟基-2-(4-羟基苯基)苯并[B]噻酚-3-基][4-[2-(1-哌啶基)乙氧基]苯基]甲酮 - Use
Open Data Verified Data
It was developed by the U. S. Lily and company and was launched in the United States in January 1998. Estrogen receptor modulators, in the uterus and breast tissue showed antagonistic estrogen effect, inhibition of mammary epithelial and endometrial hyperplasia. In the aspect of bone lipid metabolism showed Excitatory effect, with the role of estrogen. The combination of raloxifene and calcium preparations can prevent bone loss, maintain bone density and reduce blood wax.
Last Update：2022-01-01 09:24:21
![[6-羟基-2-(4-羟基苯基)苯并[B]噻酚-3-基][4-[2-(1-哌啶基)乙氧基]苯基]甲酮](http://res.chembk.com/assets/str/2d/8/84/84449-90-1.png)
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Multiple SpecificationsSpot supply
Product Name: Keoxifene; LY156758 free base; LY139481 Visit Supplier Webpage Request for quotationCAS: 84449-90-1
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Product Name: Raloxifene Visit Supplier Webpage Request for quotationCAS: 84449-90-1
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Product Name: Raloxifene Visit Supplier Webpage Request for quotationCAS: 84449-90-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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Multiple SpecificationsSpot supply
Product Name: Keoxifene; LY156758 free base; LY139481 Visit Supplier Webpage Request for quotationCAS: 84449-90-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Raloxifene Visit Supplier Webpage Request for quotationCAS: 84449-90-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Raloxifene Visit Supplier Webpage Request for quotationCAS: 84449-90-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
View History
[6-羟基-2-(4-羟基苯基)苯并[B]噻酚-3-基][4-[2-(1-哌啶基)乙氧基]苯基]甲酮
三(2-苯基吡啶)合铱 TRIS(2-PHENYLPYRIDINE)IRIDIUM
5-甲基-1H-苯并[E][1,4]二氮杂卓-2(3H)-酮
Fumaric acid ditetradecyl ester
ISOPYRIDOXAL HYDROCHLORIDE
鲸蜡基乙基二甲基溴化铵
(+)-B-CITRONELLOL
三(2-苯基吡啶)合铱 TRIS(2-PHENYLPYRIDINE)IRIDIUM
5-甲基-1H-苯并[E][1,4]二氮杂卓-2(3H)-酮
Fumaric acid ditetradecyl ester
ISOPYRIDOXAL HYDROCHLORIDE
鲸蜡基乙基二甲基溴化铵
(+)-B-CITRONELLOL